This study evaluated the efficacy of yeast extract (YE) and Aloe vera gel (AVG) as eco-friendly bio stimulants for enhancing vegetative growth, leaf chemical composition, and biomass accumulation of Fittonia albivenis (Verschaffeltii Group), a commercially significant indoor foliage plant in two seasons (2024 and 2025). A Randomized Complete Block Design (RCBD) was employed with seven treatments across three replications: a distilled water control (C) and three concentrations each of YE (1%, 2%, 3%) and AVG (1%, 2%, 5%), applied as foliar sprays every two weeks over a 90-day period under controlled greenhouse conditions. Morphological parameters assessed included: leaf area (cm²), number of leaves per stem, stem diameter (mm), leaf fresh weight (g), and leaf dry weight (g). Chemical analysis comprised total chlorophyll content (mg g⁻¹ FW) and leaf concentrations of nitrogen (N%), phosphorus (P%), and potassium (K%). Also, Catalase and Peroxidase enzymes were analyzed. Total phenolic and flavonoids were taken a place in chemical analysis. Results demonstrated that both bio stimulants conferred statistically significant improvements over the control across all measured parameters (p ≤ 0.05). Yeast Extract at 2% (Y₂) yielded the highest values for leaf area (265.4 cm²), stem diameter (5.4 mm), leaf fresh weight (16.82 g), leaf dry weight (3.62 g), total chlorophyll (2.15 mg g⁻¹ FW), and N, P, K concentrations. Aloe vera Gel at 2% (A₂) recorded competitive improvements across all parameters and is recommended as a sustainable alternative for commercial ornamental production. Both Y₂ and A₂ are proposed as optimal bio stimulant treatments for the commercial cultivation of Fittonia albivenis.