A field experiment was conducted during Rabi 2025-26 at Crop Research Farm, Department of Agronomy, PRSU, Prayagraj (U.P). The soil of experimental plot was sandy loam in texture, nearly neutral in soil reaction (pH 7.1), low in organic carbon (0.36 %), available N (171.48 kg/ha), available P (15.2 kg/ha) and available K (232.5 kg/ha). The experiment was laid out in Randomized Block Design with nine treatments each replicated thrice on the basis of one year experimentation. Among the treatments, T9 Isoproturon @ 1.50 kg/ha (post and pre-emergence) recorded the maximum plant height (101.67 cm), number of tillers per square meter (329.80), Leaf area index (3.97), and dry matter accumulation (781.76 g/m-2) at all stages, indicating better vegetative growth. However, the highest grain yield (46.83 q/ha), straw yield (109.7 q/ha), and biological yield (156.53 q/ha) were recorded under T9 Isoproturon @ 1.50 kg/ha (post and pre-emergence), which was significantly superior in terms of yield and yield-attributing characters Number of earhead m-2 (384.85), Number of grain per earhead (51.52), Weight of earhead (2.9 g), Length of earhead (9.24 cm), Test weight (42.6 g), Seed yield (46.83 q/ha), Straw yield (109.7 /ha), Biological yield (156.53 q/ha). The study concludes that weed management, especially the application of herbicide combination with Carfentrazone-ETHYL 40% DF 250 g/ha (T6), significantly enhances the growth, yield, and profitability of wheat under the agro -climatic conditions of Southern Uttar Pradesh.