A field experiment was conducted during Kharif- 2017 in sultanpur district uttar pradesh to study the effect of weed control practices on growth, yield and economics of transplanted rice. The soil was medium light grey clay loam with medium fertility status. The results of this experiment revealed that hand weeding twice (18 and 42 DAT) recorded significantly higher growth parameters of rice viz. number of tillers m^-2, LAI and total dry mater production plant^-1(323.00, 1.40 and 68.71 g, respectively) as compared to weedy check (212.67, 0.24 and 40.92 g, respectively). The highest grain and straw yields were recorded with hand weeding twice at 18 and 42 DAT (5415 and 5783 kg ha^-1, respectively) followed by application of pendimethalin 38.7 % CS @ 680 g a.i/ha as PE fb bispyribac sodium 10 % SC @ 25 g a.i/ha (4990 kg ha^-1 and 5433 kg ha^-1) and bispyribac sodium 2%+ 2,4-D sodium salt 54.3% SP @ (25+678.75) g a.i/ha with adjuvant @ 625 ml/ha (4922 and 5372 kg ha^-1, respectively). The benefit cost ratio was significantly higher with bispyribac sodium 2%+ 2,4-D sodium salt 54.3% SP @ (25+678.75) g a.i/ha with adjuvant @ 625 ml/ha (2.62) as compared to weed free check (2.47). Weed management with weedicides improves soil health compare to weeding by manually. This is due to incorporation of organic matter in soils. Weedicides are more economical than farmers practices (Mannual weeding).