The field experiment was conducted at Kandahar University, Agriculture Faculty research farm in Kandahar, Afghanistan on 2020 to determine the effect of FYM and plant growth promoting rhizobacteria (PGPR) on soybean grain yield and economics. The site of the experiment was located between 31°, 38′ of north latitude and 65°, 41′ of east longitude with 1,100m elevation. The climate of the region is semiarid with average 190mm annual precipitation. The experiment was laid out in randomized complete block design (RCBD), consisted of two factors such as farm yard manure (FYM) and PGPR; with total eight treatments combined with three replications. Four levels of FYM such as 0 (control), 7, 14 and 21 t ha-1 were each used with and without PGPR. The result showed that combined application of FYM + PGPR remarkably increased pod number per plant, seed number per pod, pod length, grain yield, straw yield and biological yield compared to control and only FYM application. The highest gross return, net return, monetary efficiency and production efficiency were also calculated from the combined application of FYM + PGPR. However, the highest cost of cultivation was also calculated in combined application of FYM + PGPR compared to only FYM application and control. Finally, due to the findings and cost of cultivation, the application of 14 ton/ha FYM with biofertilizer seems to be economically suitable for the farmers.