The objective of this study was to determine the combination dose of N-synthetic fertilizer and wedelia compost for Chinese water spinach (Ipomea reptans Poir) growth and yield. Field research was carried out from May to June 2020 in Sambirejo Village, Selupu Rejang District, Rejang Lebong Regency, Bengkulu, Indonesia, at an altitude of ±1100 m above sea level. The study employed a completely randomized design (CRD) with a single treatment factor, namely a combination of synthetic N fertilizer and wedelia compost dosage. The treatments have included combination of 200 kg/ha urea and no compost; 160 kg/ha urea and 6 tons/ha compost; 120 kg/ha urea and 12 tons/ha compost; 80 kg/ha urea and 18 tons/ha compost; 40 kg/ha urea and 24 tons/ha compost; and 30 tons/ha compost. Each treatment was repeated three times. The application of 160 kg/ha urea + 6 tons/ha compost and 120 kg/ha urea + 12 tons/ha compost resulted more in Chinese water spinach fresh weight per plant, and fresh weight per plot than the 40 kg/ha urea treatment. + 24 tons/ha of compost and 30 tons/ha of compost. The stem diameter and greenness of Chinese water spinach leaves did not differ between plants fertilized only with urea and compost or with a mixture of urea and compost at various doses. Therefore conjunctive use of compost and inorganic fertilizer made it possible to reduce inorganic fertilization.