The extinction comes near to the plant Commiphora wightii (Arn.) Bhandari, one the most pharmacologically and economically important slow-growing small tree belongs to a Genus Commiphora and the Burseraceae family. It is a flowering, dioecious plant, used in ayurvedic and Unani medicine in treating various ailments and disorders. It is commonly known as “Guggul” because of the presence of secondary metabolites “Guggulsterone” in oleo-gum resin. The species is now listed in the Red Data Book of IUCN because of the overexploitation of oleo-gum resin by the local population for economic benefits with no conservation efforts. This plant has much adequate attention on its conservation but it has not been focused yet. Conventional methods for the propagation of Commiphora wightii (Arn.) Bhandari are; the seeds, vegetative method through stem cuttings and air layering but they have many limitations too; seeds with slow-growing nature, poor seed set, poor seed germination due to hard endocarp, estimated 10% of seedling destroyed by insects and pests. Therefore, more advanced techniques involvement is important and beneficial to overcome these difficulties. Micropropagation is one of the most common and important biotechnological method which can develop a reliable and rapid protocol for its conservation. Despite many reports on the propagation of Guggul, tissue culture raised efficient plantlets for field performance has not been yet initiated. For commercial-scale efficient plantlet production, scientific studies are required to focus on the multiplication protocol and survival rates of plantlets in the greenhouse. An effective protocol for multiplication with the higher adaptive rate of the plant in field conditions can open the door for many future advances like breeding, embryogenic culture establishment, genetic transformation for resistance verities, higher production of oleo-gum resin, pharmaceutically active compound production and many more. Conservation efforts will require the involvement of local people and villagers. Scientific tapping practices are also required so that the plant is not killed after tapping.