Global climate change is one of the major issues in the current century which has sizable impact on the livelihood. The effects of climate change on our ecosystems are already severe and widespread, and ensuring food security in the face of climate change is among the most daunting challenges facing humankind. While some of the problems associated with climate change are emerging gradually. Afghanistan is ranked among the most vulnerable countries in the world to the adverse impacts of climate change. The horticulture subsector Contributes US$1.4 billion to the national GDP of the country. Tomato cultivation is a source of livelihood to most farmers in the country. Rising temperature and erratic rainfall pattern which are attributed to the varying climate have been the bane of the tomato farmers. The general consensus is that changes in temperature and precipitation will result in changes in land and water regimes that will subsequently affect agricultural productivity. The aim of this study was to improve understanding of the effects of climate change on grape crop production in the Lashkargah District of Helmand Province, Afghanistan under stipulated years of 2008-2017. The result of the study suggests an increase in both maximum and minimum temperatures coupled with decrease in annual precipitation in an unreliable seasonal distribution over the last ten years. The study identified incidence of pests and diseases the major effect of climate variability on grape production as reported by the farmers in the District. The study highlights the role of climate variables (temperature and precipitation) on grape production area while controlling other confounding variables. The study found that an increase in temperature caused a significant decrease in grape production while some confounding variables such as market availability, irrigation water availability, pests and diseases, etc., held constant. The study further found a statistically positive relationship between precipitation and grape production. The implication is that as precipitation decreases, it potentially causes a reduction in area under grape productions.