Cowpea is a widely consumed pulse to address protein deficiency but its potential for Zinc bio-fortification is not widely studied in West Africa and optimal rates for different cowpea varieties are not known. In connection with this field and pot experiments were conducted in the major and minor seasons of 2016 to investigate the effect of Zn fertilizer on the growth, yield and nutritional benefits to cowpea. Three early maturing cowpea varieties (Asontem, Agyenkwa and Zamzam) were grown in both experiments and Zn fertilizer rates of 0, 5 and 10 kg/ha were applied into them. The Zn fertilizer was applied as foliar application in both experiments. The split plot design was used for both studies. All recommended cultural practices were timely done. The results showed that Zn application improved leaf area index and shoot dry matter. Grain yield and harvest index were also enhanced following the Zn fertilizer application. Furthermore, Zn fertilizer application resulted in increase in the Zinc contents of cowpea haulms and grains. The results indicated that Zn fertilizer application can lead to better growth, yield and nutrient quality. This will not only improve cowpea nutrition, but cost use of Zn supplements in humans will be reduced.