Background: Over the years a lot of difficulties are usually encountered in the mass propagation of most woody tree species, and irvingia is not excluded. This study was design to compare the performances of five different root inducing substrates in vegetative propagation (marcotting) of irvingia gabonensis. Materials and Methods:Five different root inducing substrates (River sand, Top soil, Poultry droppings, Cow dungs and Chromolena odorata grinded leaves) were used to induce roots in I. gabonensis marcotted branches. After two weeks of marcotting, selected branches were checked weekly for root emergence and leaves performance. Data collected on root emergence and leaves performance were subjected to a two ways analysis of variance in order to determine the significant difference between means. Results: The results revealed that 50% of branches that were marcotted with root inducing substrate of C. odorata grinded leaves lost their leaves. After two weeks of marcotting, there was root emergence of an average root length of 1.5cm on the branches that were marcotted with C. odorata grinded leaves (Sample E). Branches marcotted with other root inducing substrates produced callus only. It was observed that 55% of branches that were marcotted with C odorata died after eight weeks of marcotting. Conclusion:Early emergence of roots was achieved when C odorata grinded leaves was used as root inducing substrate in the vegetative propagation of I. gabonensis. C. odorata grinded leave can be used as root inducing substrate when carrying out vegetative propagation of I. gabonensis through marcotting.